NMR Service intern

NMR Service extern

Contact Us


InsightMR


New @DCB in our group

Monitoring Chemical and Biological Processes
InsightMR has a varied portfolio of applications for monitoring chemical and biological processes, to increase understanding of reaction mechanisms, radical formation and cell metabolism. InsightMR "the classic", enhances reaction understanding, and confidence when transferring processes from the laboratory to the manufacturing plant. The InsightMR flow unit and dedicated software are ideal for both industrial and academic scientists studying or optimizing organic reactions. The flow unit, equipped with temperature-controlled transfer lines, enables on-line monitoring of chemical reactions in real-time under real conditions. This is achieved by fast and continuous transfer of reaction mixtures from a reaction vessel into the flow tube, which is located in the NMR probe. The InsightMR flow unit is compatible with all 5 mm Bruker probes, making it a cost-effective, versatile solution.
(Source: the resonance)

What is with our setup possible?

  •  

    Temperature range in the flow path:                                                 

    278 K (5 °C) to 318 K (45 °C)

     

    Atmosphere:

    Air or inert

     

    Reflux:

    Yes

     

    Reaction solvent:

    Non- and/or deuterated (depending on the concentration and/or sensitivity of the nucleus) not reacting with glass, PTFE, graphite fiber, FKM, PEEK, sapphire, aluminum oxide (Al2O3), titanium and/or ceramic

     

    Experiments:

    1H/13C/X (depending on the concentration and/or sensitivity of the nucleus)

     

    Reaction vessel:

    whatever you have (min. volume limitation)

     

    Pressure:

    < 10 bar

     

    Biological agents:

    below biosafety level 1

  • Software for InsightMR acquisition and processing

  • We have InsightMR a software for real-time data analysis and acquisition control for process monitoring. You could tell us how many experiments you like to have and the expected duration of reactions. For a 1H experiment with ns=4 we could record a spectra every 50 seconds. You would be able to follow your reaction live. Later, back in the office, you could process your experiments with the Bruker Topspin (free license for academia) and the free Dynamics Center. You like to try first?

  •  

    Download and install Topspin and Dynamics Center (both with integrated manuals) with your Bruker account (MS Windows, Linux or MAC):

    Bruker NMR Software

     

    Download and extract example data (< 13 MB):

    ExsampleInsightMR.zip

  • External publications with InsightMR

    Twitter #InsightMR

  • K. Lauder, A. Toscani, Y. Qi, J. Lim, S. J. Charnock, K. Korah, D. Castagnolo
    "Photo-biocatalytic One-Pot Cascades for the Enantioselective Synthesis of 1,3-Mercaptoalkanol Volatile Sulfur Compounds"
    Angewandte Chemie, 130 (20), 5905-5909, 2018 DOI: 10.1002/ange.201802135

  • A. L. Dunn, A. Codina, D. A. Foley, B. L. Marquez, M. T. Zell
    "A detailed mechanistic investigation into the reaction of 3-methylpentanoic acid with Meldrum's acid utilizing online NMR spectroscopy"
    MRC, 54 (6), 477-484, 2016 DOI: 10.1002/mrc.4317

  • D. A. Foley, E. Bez, A. Codina, K. L. Colson, M. Fey, R. Krull, D. Piroli, M. T. Zell, B. L. Marquezl
    "NMR Flow Tube for Online NMR Reaction Monitoring"
    Analytical Chemistry, 86 (24), 12008-12013, 2014 DOI: 10.1021/ac502300q


  • Site under cunstruction - more info follow! (05.10.19/sw)