NMR SPECTROSCOPY

Teaching

Analytical Chemistry I (HS)
The lecture conveys the fundamentals of modern instrumental analysis for the elucidation of molecular structures. Emphasis is placed on mass spectrometry (MS), infrared spectroscopy (IR), and nuclear magnetic resonance (NMR) spectroscopy.

Analytical Chemistry II (FS)
The lecture builds on the knowledge acquired in "Analytical Chemistry I" and teaches the application of key analytical techniques for the elucidation of molecular structures. The focus is on infrared spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR), and mass spectrometry (MS). The lecture includes practical sessions. Introduction to modern structure elucidation using IR and nuclear magnetic resonance spectroscopy (NMR). Lecture: Theory, fundamentals, examples, application of methods for structure elucidation and structure verification.

Analytical Chemistry III (HS)
Overview of the modern strategies, tactics, and applications of NMR and MS. The content includes the evaluation of one- and two-dimensional NMR methods for solving complex structural problems, tandem mass spectrometric methods for sequencing of biomolecules, and screening methods for identification and quantitation of compounds in complex mixtures.

Methods in Biochemistry II with Exercises (FS)
This lecture series covers classical as well as state-of-the-art methods in biochemistry, molecular biology, bioinformatics and structural biology. In particular experimental approaches to study nucleic acids, proteins and lipids as well as different aspects of structural biology (NMR, X-ray, EM) will be introduced.

Medicinal Inorganic Chemistry (FS)
Medicinal inorganic chemistry is a relatively young, interdisciplinary research area that has grown primarily due to the success of cisplatin, a Pt-based anticancer drug developed in the late 1960s. Currently, metal complexes are used in many areas of medicine including anticancer and antimicrobial. The rational design of metal-based drugs is therefore a relatively new concept, facilitated by improvements in characterization and imaging techniques. During the lecture, it will be shown and emphasized that a metal complex that is administered is likely to be a prodrug that undergoes a transformation in vivo before reaching its target sites. Elucidating the precise mechanisms of action of these new drugs is perhaps the most challenging and complicated aspect of the research, because it requires drawing together knowledge concerning the reactivity of the metal complex. During the lectures, using selected examples, we provide an overview of the uses of metal-based drugs in these diverse medical fields and, where appropriate, we guide the students to publications that provide a more in-depth analysis.

Advanced NMR (HS)
This course includes several independent chapters and exercises, included in the chapters or independent, calling for more global knowledge. The topics covered are the following: I. Basic principles of NMR spectroscopy as well as important aspects such as relaxation, sensitivity, quantitative NMR. II. Heteronuclear NMR, including quadrupolar nuclei. III. Second order effects, including simulation exercises. IV. 2D NMR spectroscopy, including discussions on the measurement time of the different 1D & 2D NMR experiments and their feasibility for routine measurements. V. Homonuclear and heteronuclear NOE effect. VI. NMR data acquisition and processing, including data processing exercises. VII. Concluding chapter, aiming to show how to reduce the risk of deducing wrong structures from NMR data. Exercises, consisting in assigning signals, proving structures and their stereochemistry. The exercises should help the students to independently analyze complex 1D and 2D NMR spectra. During the exercises, the strengths / weaknesses of the different NMR methods are discussed and highlighted.

NMR Tutorial
Interactive learning platform to understand the response of nuclear spin system when exposed to 1D AND 2D NMR Experiments.