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Dr. Martina Vermathen

Born 1965 in Wilhelmshaven, Germany.


Abitur, “Max-Planck-Gymnasium” Wilhelmshaven, Germany.

1984 - 1989

Study of Food Chemistry. University of Münster, Germany.


Graduation in Food Chemistry, University of Münster, Germany.

10/1991 - 06/1995

PhD in Chemistry, University of Münster, Department of Pharmaceutical Biology & Phytochemistry.

03/1996 - 07/1996

Research Assistant, University of California San Francisco (UCSF), USA. In vitro HR NMR spectroscopy on rat brain preparations.

08/1996 - 12/1997

Postdoctoral Fellow, University of California San Francisco (UCSF), VA Medical Center, USA. In vivo NMR spectroscopy on patients with Multiple Sclerosis.

12/1997 - 11/1999

Postdoctoral Fellow, San Francisco State University (SFSU), Dep. Chemistry & Biochemistry, San Francisco, USA. HR NMR spectroscopy on micellar systems with incorporated porphyrins and benzoates, Synthetic work (tetraphenylporphyrins).

Since 01/2003

Research Assistant. Department of Chemistry & Biochemistry, University of Bern, Switzerland. HR NMR and HR-MAS NMR spectroscopy; responsible for various research projects.
Service measurements and maintenance of NMR spectrometers.





Research Interests

1. Drug delivery for porphyrinic photosensitizers in photodynamic therapy (PDT)


Nanocarriers for topical PDT
- Bicelles and their potential as carriers for topical PDT
- NMR characterization of structural and dynamic bicelle properties
- Skin penetration and cell uptake
- Fluorescence spectroscopy and fluorescence lifetime imaging of porphyrins in cells and tissue (collaboration     with M. Frenz, Biomedical Photonics, Inst. Applied Physics)


Polymeric nanocarriers for systemic PDT
- Block copolymer micelles, polyvinylpyrrolidone and other materials
- Encapsulation of porphyrins into the carrier systemss
- NMR characterization of porphyrin-carrier systemse
- Reactivity of encapsulated porphyrins towards biomolecules
- Photophysical properties of encapsulated porphyrins

2. Porphyrinic photosensitizers and their interactions with model membranes, nanoparticles and cells


- Localization, orientation and distribution of porphyrins within and across model membranes
- Aggregation properties of amphiphilic porphyrins

3. High Resolution Magic Angle Spinning (HR-MAS) NMR spectroscopy applications (Collaboration with   P. Vermathen AMSM, Inselspital, siteminsel)


HR-MAS NMR based metabolomic studies on cells and tissue samples
- HR-MAS NMR investigations of cellular profiles following drug treatment
- Cellular uptake of porphyrins by HeLa cells
- HR-MAS NMR of porcine skin samples: Porphyrin / carrier uptake; lipid dynamics
- Metabolic profiling of protozoan parasites (collaboration with J. Müller and N. Müller, Inst. Parasitology,       Vetsuisse Faculty)
- Metabolic profiling of cisPt-resistant cancer cells (collaboration with H. von Tengg-Kobligk, Experimental       Radiology, DBMR, Inselspital)


HR-MAS NMR for the analysis of active pharmaceutical ingredients (APIs) in semi-solid pharmaceutical or cosmetic emulsions
- Direct analysis of APIs in creams, pastes and ointments
- Method development for quantification of corticosteroids in topical pharmaceutical formulations


HR-MAS NMR based metabonomic studies of apples
- Impact of different production systems and storage conditions on the metabolic profile of apples            (Collaboration with Agroscope, Wädenswil, CH)